I've always used this excellent pair of blog posts by Bill Clementson to get lispworks personal working with emacs/slime on windows.

Configuring SLIME for 3 Win32 CL Implementations
Using LispWorks Personal with Emacs/SLIME on Windows

Having had the joy of a hard drive failure last week I had to reinstall everything, and I've found that with the latest CVS version of slime you need to change your ".slime.lisp" file to look like this:

(load "/YOURPATHTOSLIME/slime/swank-loader.lisp")
(swank::create-server :port 4005)

So if your slime/lispworks personal setup stops working when you upgrade slime, hopefully you found your way here.